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Journal article

Five computational developability guidelines for therapeutic antibody profiling

Abstract:

Therapeutic mAbs must not only bind to their target but must also be free from “developability issues” such as poor stability or high levels of aggregation. While small-molecule drug discovery benefits from Lipinski’s rule of five to guide the selection of molecules with appropriate biophysical properties, there is currently no in silico analog for antibody design. Here, we model the variable domain structures of a large set of post-phase-I clinical-stage antibody therapeutics (CSTs) and calc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1810576116

Authors


Raybould, MIJ More by this author
Krawczyk, K More by this author
Taddese, B More by this author
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
10
Pages:
4025-4030
Publication date:
2019-02-14
Acceptance date:
2019-01-10
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:967532
URN:
uri:8a952eb2-108c-4a19-b181-bb9f89b4727c
UUID:
uuid:8a952eb2-108c-4a19-b181-bb9f89b4727c
Local pid:
pubs:967532

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