Preprint
Viral cultures, PCR Cycle threshold values and viral load estimation for COVID-19 infectious potential assessment in transplant patients: systematic review - Protocol
- Abstract:
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This is the protocol for a systematic review focussing on people receiving solid organ or hematopoietic stem cell transplants.
Our research questions are as follows:
What is the relationship between serial PCR Ct value or other measures of viral burden, and the likelihood and duration of the presence of infectious virus from viral culture, among transplant recipients with SARS-CoV-2 infection?
What is the influence of age, sex, underlying pathologies, degree of immunosuppression, vaccination status, COVID-19 symptoms and COVID-19 disease course on viral burden and the likelihood of presence of infectious SARS-CoV-2?
We will include single studies reporting serial Cts from sequential rt-PCR testing or other measures of viral burden such as RNA gene copies of respiratory samples (from nasopharyngeal specimens) along with viral culture data on the same samples, from patients about to receive a transplant or who are post transplant with SARS-CoV-2 infection.
- Publication status:
- Published
- Peer review status:
- Not peer reviewed
Actions
Access Document
- Files:
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(Preview, Pre-print, pdf, 116.6KB, Terms of use)
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- Preprint server copy:
- 10.1101/2021.12.30.21268509
Authors
+ World Health Organization
More from this funder
- Funder identifier:
- https://ror.org/01f80g185
- Grant:
- 2020/1077093-0
- 2021/1138353-0
+ National Institute for Health and Care Excellence
More from this funder
- Funder identifier:
- https://ror.org/015ah0c92
- Programme:
- Evidence Synthesis Working Group [Project 569]
+ Canadian Institutes of Health Research
More from this funder
- Funder identifier:
- https://ror.org/01gavpb45
+ Natural Sciences and Engineering Research Council of Canada
More from this funder
- Funder identifier:
- https://ror.org/01h531d29
- Preprint server:
- medRxiv
- Publication date:
- 2022-01-01
- DOI:
- Language:
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English
- Pubs id:
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1262019
- Local pid:
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pubs:1262019
- Deposit date:
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2026-02-25
- ARK identifier:
Terms of use
- Copyright holder:
- Jefferson et al.
- Copyright date:
- 2022
- Rights statement:
- The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license .
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