Journal article
How is alpha‐synuclein cleared from the cell?
- Abstract:
-
The levels and conformers of alpha‐synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha‐synuclein at different stages of its intracellular trafficking and transcellular propagation. Here we review pathways involved in the removal of various forms of alpha‐synuclein from both the intracellular and extracellular environment. Proteasomes and lysosome...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Neurochemistry Journal website
- Volume:
- 150
- Issue:
- 5
- Pages:
- 577-590
- Publication date:
- 2019-05-08
- Acceptance date:
- 2019-04-05
- DOI:
- EISSN:
-
1471-4159
- ISSN:
-
0022-3042
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1003441
- UUID:
-
uuid:8a8efac0-6d2d-43d6-b40d-c8e6a45c5ea8
- Local pid:
- pubs:1003441
- Source identifiers:
-
1003441
- Deposit date:
- 2019-06-29
Terms of use
- Copyright holder:
- International Society for Neurochemistry
- Copyright date:
- 2019
- Rights statement:
- © 2019 International Society for Neurochemistry.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1111/jnc.14704
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