Journal article icon

Journal article

How is alpha‐synuclein cleared from the cell?

Abstract:

The levels and conformers of alpha‐synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha‐synuclein at different stages of its intracellular trafficking and transcellular propagation. Here we review pathways involved in the removal of various forms of alpha‐synuclein from both the intracellular and extracellular environment. Proteasomes and lysosome...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1111/jnc.14704

Authors


More from this funder
Name:
Innovative Medicines Initiative 2 project IMPRiND
Grant:
116060
Publisher:
Wiley
Journal:
Journal of Neurochemistry More from this journal
Volume:
150
Issue:
5
Pages:
577-590
Publication date:
2019-05-08
Acceptance date:
2019-04-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
Language:
English
Keywords:
Pubs id:
pubs:1003441
UUID:
uuid:8a8efac0-6d2d-43d6-b40d-c8e6a45c5ea8
Local pid:
pubs:1003441
Source identifiers:
1003441
Deposit date:
2019-06-29

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP