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norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis

Abstract:
Background & Aim Primary sclerosing cholangitis (PSC) represents a devastating bile duct disease, currently lacking effective medical therapy. 24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties in a preclinical PSC mouse model. A randomized controlled trial, including 38 centers from 12 European countries, evaluated the safety and efficacy of three doses... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jhep.2017.05.009

Authors


Fickert, P More by this author
More by this author
ORCID:
0000-0002-6736-2255
Marschall, H-U More by this author
Altorjay, I More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Hepatology Journal website
Volume:
67
Issue:
3
Pages:
549-558
Publication date:
2017-05-18
Acceptance date:
2017-05-06
DOI:
EISSN:
1600-0641
ISSN:
0168-8278
Pubs id:
pubs:900890
URN:
uri:8a82ad46-7070-46f2-bf70-23d149e84a68
UUID:
uuid:8a82ad46-7070-46f2-bf70-23d149e84a68
Local pid:
pubs:900890

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