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Averting inflammation by targeting the cytokine environment.

Abstract:

Cytokines are key instigators and regulators of immune responses and therefore hold great potential as targets for new therapeutic strategies. However, the selection of which cytokines to target, and in particular the identification of which cytokines regulate the rate-limiting steps of disease pathways, is crucial to the success of such strategies. Moreover, balancing the need for ablating pathological inflammatory responses and simultaneously maintaining the ability to control infectious ag...

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Publication status:
Published

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Publisher copy:
10.1038/nrd2805

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Marsland, BJ More by this author
Journal:
Nature reviews. Drug discovery
Volume:
9
Issue:
9
Pages:
703-718
Publication date:
2010-09-05
DOI:
EISSN:
1474-1784
ISSN:
1474-1776
URN:
uuid:8a808f36-afa9-4191-b876-e764a95b375b
Source identifiers:
422335
Local pid:
pubs:422335

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