Journal article
Heparin versus citrate anticoagulation for continuous renal replacement therapy in intensive care: the RRAM observational study
- Abstract:
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Background: In the UK, 10% of admissions to intensive care units receive continuous renal replacement therapy with regional citrate anticoagulation replacing systemic heparin anticoagulation over the last decade. Regional citrate anticoagulation is now used in > 50% of intensive care units, despite little evidence of safety or effectiveness.
Aim: The aim of the Renal Replacement Anticoagulant Management study was to evaluate the clinical and health economic impacts of intensive care units moving from systemic heparin anticoagulation to regional citrate anticoagulation for continuous renal replacement therapy.
Design: This was an observational comparative effectiveness study.
Setting: The setting was NHS adult general intensive care units in England and Wales.
Participants: Participants were adults receiving continuous renal replacement therapy in an intensive care unit participating in the Intensive Care National Audit & Research Centre Case Mix Programme national clinical audit between 1 April 2009 and 31 March 2017.
Interventions: Exposure – continuous renal replacement therapy in an intensive care unit after completion of transition to regional citrate anticoagulation. Comparator – continuous renal replacement therapy in an intensive care unit before starting transition to regional citrate anticoagulation or had not transitioned.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.5MB, Terms of use)
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- Publisher copy:
- 10.3310/zxhi9396
Authors
- Publisher:
- National Institute for Health and Care Research (NIHR)
- Journal:
- Health Technology Assessment More from this journal
- Volume:
- 26
- Issue:
- 13
- Pages:
- 1-58
- Place of publication:
- England
- Publication date:
- 2022-02-01
- DOI:
- EISSN:
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2046-4924
- ISSN:
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1366-5278
- Pmid:
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35212260
- Language:
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English
- Keywords:
- Pubs id:
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1241515
- Local pid:
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pubs:1241515
- Deposit date:
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2023-07-04
Terms of use
- Copyright holder:
- Queen’s Printer and Controller of HMSO
- Copyright date:
- 2022
- Rights statement:
- © Queen’s Printer and Controller of HMSO 2022. This work was produced by Gould et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
- Licence:
- CC Attribution (CC BY)
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