Journal article
Functional differences exist between TNF(alpha) promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.
- Abstract:
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A large body of functional and epidemiological evidence have previously illustrated the impact of specific MHC class I subtypes on clinical outcome during HIV-1 infection, and these observations have recently been re-iterated in genome wide association studies (GWAS). Yet because of the complexities surrounding GWAS-based approaches and the lack of knowledge relating to the identity of rarer single nucleotide polymorphism (SNP) variants, it has proved difficult to discover independent causal ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 444.0KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0040100
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Funding
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PloS one More from this journal
- Volume:
- 7
- Issue:
- 7
- Article number:
- e40100
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
-
- UUID:
-
uuid:8a6c0636-5c36-4886-b6b0-91817738680a
- Local pid:
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pubs:342292
- Source identifiers:
-
342292
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Simpson et al
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Simpson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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