Self-assembly of vesicle nanoarrays on Si: A potential route to high-density functional protein arrays

Journal article

The authors show that 100 nm unilamellar thiol-tagged vesicles bind discretely and specifically to Au nanodots formed on a Si surface. An array of such dots, consisting of 20 nm Au-Si three-dimensional islands, is formed by self-assembly on terraces of small-angle-miscut Si(111) after Au deposition. Consequently, both the formation of the nanopattern and the subsequent attachment of the vesicles are self-organized and occur without the need for any "top-down" lithographic processes. This approach has the potential to provide the basis of a low-cost, high-density nanoarray for use in proteomics and drug discovery. © 2007 American Institute of Physics.

Authors: Ramanujan, C; Sumitomo, K; de Planque, M; Hibino, H; Torimitsu, K

• Publication status: Published
• Journal: APPLIED PHYSICS LETTERS
• Volume: 90
• Issue: 3
• Pages: 033901-033901
• Publication date: 2007-01-15
• DOI: 10.1063/1.2431774
• ISSN: 0003-6951
• Language: English