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Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies.

Abstract:
Cholinesterase inhibitors (ChEIs) are effective symptomatic treatments in dementia with Lewy bodies (DLB), although effects on pathologic mechanisms are unknown. In the first human autopsy study examining the impact of ChEI treatment on brain pathology, we compared treated patients with DLB with matched untreated patients for cortical beta-amyloid (Abeta) and tau pathologies. Treated patients with DLB had significantly less parenchymal Abeta deposition, which is relevant to disease management and treatment of dementia patients using ChEI.
Publication status:
Published

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Authors


Ballard, CG More by this author
Chalmers, KA More by this author
McKeith, IG More by this author
O'Brien, JT More by this author
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Journal:
Neurology
Volume:
68
Issue:
20
Pages:
1726-1729
Publication date:
2007-05-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:8a6b37bf-e52c-4317-a235-1c036259b622
Source identifiers:
60823
Local pid:
pubs:60823

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