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Crystal structure of guaiacol and phenol bound to a heme peroxidase.

Abstract:

Guaiacol is a universal substrate for all peroxidases, and its use in a simple colorimetric assay has wide applications. However, its exact binding location has never been defined. Here we report the crystal structures of guaiacol bound to cytochrome c peroxidase (CcP). A related structure with phenol bound is also presented. The CcP-guaiacol and CcP-phenol crystal structures show that both guaiacol and phenol bind at sites distinct from the cytochrome c binding site and from the δ-heme edge,...

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Publication status:
Published

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Authors


Murphy, EJ More by this author
Metcalfe, CL More by this author
Nnamchi, C More by this author
Journal:
The FEBS journal
Volume:
279
Issue:
9
Pages:
1632-1639
Publication date:
2012-05-05
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
URN:
uuid:8a586db2-6135-401d-9bfa-5dea11a0d7fd
Source identifiers:
240700
Local pid:
pubs:240700

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