Diseases of the neuromuscular junction.

Journal article

The neuromuscular junction is a prototype synapse and it is also the site of well-characterised autoimmune and hereditary disorders. In the presynaptic terminal, voltage-gated potassium channels and voltage-gated calcium channels are subtly altered in genetic disorders and mutations in the enzyme that synthesises acetylcholine have been demonstrated in a particular form of hereditary myasthenia syndrome. Recent advances have revealed agrin, muscle-specific kinase (MuSK) and rapsyn as importan...

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Authors: McConville, J; Vincent, A

• Publication status: Published
• Journal: Current opinion in pharmacology
• Volume: 2
• Issue: 3
• Pages: 296-301
• Publication date: 2002-06-01
• DOI: 10.1016/s1471-4892(02)00156-x
• EISSN: 1471-4973
• ISSN: 1471-4892
• Language: English
• Keywords: Neuromuscular Junction; Synaptic Transmission; Receptors, Presynaptic; Animals; Neuromuscular Diseases; Humans; Synapses