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Journal article

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Abstract:

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechanism coupling the pulmonary clock to innate immunity, involving both myeloid and bronchial epithelial cells in temporal gating and determining amplitude of response to inhaled endotoxin. Dual mutation of REV-ERBα and its paralog REV-ERBβ in bronchial...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/JCI93910

Authors


More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
EP/H031111
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/L000954/1
More from this funder
Name:
Wellcome Trust
Grant:
107851/Z/15/Z
Publisher:
American Society for Clinical Investigation
Journal:
Journal of Clinical Investigation More from this journal
Volume:
128
Issue:
6
Pages:
2281-2296
Publication date:
2018-03-13
Acceptance date:
2018-03-08
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pmid:
29533925
Language:
English
Keywords:
Pubs id:
pubs:858644
UUID:
uuid:8a2f2c7c-2a56-4bde-befb-9e0ce6d992a0
Local pid:
pubs:858644
Source identifiers:
858644
Deposit date:
2018-10-18

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