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A protocol for dual calcium-voltage optical mapping in murine sinoatrial preparation with optogenetic pacing

Abstract:

Among the animal models for studying the molecular basis of atrial and sinoatrial node (SAN) biology and disease, the mouse is a widely used species due to its feasibility for genetic modifications in genes encoding ion channels or calcium handling and signaling proteins in the heart. It is therefore highly valuable to develop robust methodologies for studying SAN and atrial electrophysiological function in this species. Here, we describe a protocol for performing dual calcium-voltage optical...

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Publication status:
Published
Peer review status:
Peer reviewed

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Name:
British Heart Foundation
Grant:
PG/12/21/29473
Publisher:
Frontiers Media
Journal:
Frontiers in physiology More from this journal
Volume:
10
Article number:
954
Publication date:
2019-08-06
Acceptance date:
2019-07-09
DOI:
EISSN:
1664-042X
Pmid:
31456689
Language:
English
Keywords:
Pubs id:
pubs:1047044
UUID:
uuid:8a20f854-d97b-486b-9053-276fad6700f7
Local pid:
pubs:1047044
Source identifiers:
1047044
Deposit date:
2019-10-16

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