Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters.

Journal article

Using data from the UK Register of HIV Sero-converters, we compared the rate of CD4 cell decline in antiretroviral-naive individuals with and without evidence of transmitted drug resistance (TDR). Although there was a suggestion that CD4 cell decline in the first year after seroconversion was faster in those with TDR,there was no evidence of a difference in the rate of decline thereafter. The virological and host determinants of this possible phenomenon are worth further exploration.

Authors: Bhaskaran, K; Pillay, D; Walker, A; Fisher, M; Hawkins, D

• Publication status: Published
• Journal: AIDS (London, England)
• Volume: 18
• Issue: 10
• Pages: 1471-1473
• Publication date: 2004-07-01
• DOI: 10.1097/01.aids.0000131341.45795.33
• EISSN: 1473-5571
• ISSN: 0269-9370
• Language: English
• Keywords: UK Register of HIV Seroconverters; Humans; CD4 Lymphocyte Count; Lymphopenia; HIV Seropositivity; Cohort Studies; HIV Infections; CD4-Positive T-Lymphocytes; Adult; Female; Male; Drug Resistance, Viral