Journal article icon

Journal article

miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA

Abstract:

Radiation therapy is a common treatment for prostate cancer, however recurrence remains a problem. MicroRNA expression is altered in prostate cancer and may promote therapy resistance. Through bioinformatic analyses of TCGA and CPC-GENE patient cohorts, we identified higher miR-191 expression in tumor versus normal tissue, and increased expression in higher Gleason scores. In vitro and in vivo experiments demonstrated that miR-191 overexpression promotes radiation survival, and contributes to...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.canlet.2019.12.025

Authors


Publisher:
Elsevier
Journal:
Cancer Letters More from this journal
Volume:
473
Pages:
107-117
Publication date:
2019-12-23
Acceptance date:
2019-12-19
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
Pmid:
31874245
Language:
English
Keywords:
Pubs id:
pubs:1080463
UUID:
uuid:8a00cbb8-cca5-4260-8613-999fa5a37c5c
Local pid:
pubs:1080463
Source identifiers:
1080463
Deposit date:
2020-01-02

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP