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Radionuclide spatial distribution and dose deposition for in vitro assessments of 212Pb‐αVCAM‐1 targeted alpha therapy

Abstract:

Purpose Targeted alpha therapy (TAT) takes advantage of the short‐range and high‐linear energy transfer of α‐particles and is increasingly used, especially for the treatment of metastatic lesions. Nevertheless, dosimetry of α‐emitters is challenging for the very same reasons, even for in vitro experiments. Assumptions, such as the uniformity of the distribution of radionuclides in the culture medium, are commonly made, which could have a profound impact on dose calculations. In this study we ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/mp.13969

Authors


More from this funder
Name:
Cancer Research UK
Grant:
16466
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
EP/L024012/1
Publisher:
Wiley
Journal:
Medical Physics More from this journal
Volume:
47
Issue:
3
Pages:
1317-1326
Publication date:
2019-12-15
Acceptance date:
2019-12-13
DOI:
EISSN:
2473-4209
ISSN:
0094-2405
Language:
English
Keywords:
Pubs id:
pubs:1078363
UUID:
uuid:89ef15fa-214f-4080-a1d4-b84f9278ee19
Local pid:
pubs:1078363
Source identifiers:
1078363
Deposit date:
2019-12-18

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