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Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein.

Abstract:

gamma-Aminobutyric acid (GABA) synthesis in the brain is mediated by two major isoforms of glutamic acid decarboxylase, GAD(65) and GAD(67). The contribution of these isoforms to GABA synthesis flux (V(GAD)) is not known quantitatively. In the present study we compared V(GAD) in cortex of control and vigabatrin-treated rats under alpha-chloralose/70% nitrous oxide anesthesia, with total GAD activity and GAD isoform composition (GAD(65) and GAD(67)) measured by enzymatic assay and quantitative...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Brain research More from this journal
Volume:
914
Issue:
1-2
Pages:
81-91
Publication date:
2001-09-01
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
Language:
English
Keywords:
Pubs id:
pubs:131295
UUID:
uuid:89e9827c-3a13-4306-ad02-99beea590172
Local pid:
pubs:131295
Source identifiers:
131295
Deposit date:
2012-12-19

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