Journal article icon

Journal article

Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

Abstract:

Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Magnetic resonance imaging (MRI) has demonstrated its potential for detecting the pathological signature and tracking disease progression in ALS. However, the microstructural and molecular pathological substrate is poorly understood and generally defined histologically. One route to unders...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1186/s12868-018-0416-1

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-5117-0120
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Engineering and Physical Sciences Research Council and Medical Research Council
Funding agency for:
Huszar, I
Grant:
EP/L016052/1
More from this funder
Name:
Medical Research Council
Grant:
MR/K02213X/1
Publisher:
BioMed Central
Journal:
BMC neuroscience More from this journal
Volume:
19
Issue:
11
Pages:
1-24
Publication date:
2018-03-13
Acceptance date:
2018-03-02
DOI:
ISSN:
1471-2202
Pmid:
29529995
Language:
English
Keywords:
Pubs id:
pubs:829593
UUID:
uuid:89e7cad3-4b02-4ee0-be23-69960ef1e23d
Local pid:
pubs:829593
Deposit date:
2018-04-04

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP