Regulatory T cells in transplantation.

Journal article

Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection.

Authors: Waldmann, H; Chen, T; Graca, L; Adams, E; Daley, S

• Publication status: Published
• Journal: Seminars in immunology
• Volume: 18
• Issue: 2
• Pages: 111-119
• Publication date: 2006-04-01
• DOI: 10.1016/j.smim.2006.01.010
• EISSN: 1096-3618
• ISSN: 1044-5323
• Language: English
• Keywords: Animals; Humans; Transplantation Tolerance; T-Lymphocytes, Regulatory