Fatty acid metabolism in patients with PPARgamma mutations.

Journal article

CONTEXT: PPARG mutations may cause insulin resistance and dyslipidemia, but little is known about the mechanisms of the abnormalities of lipid metabolism. OBJECTIVE: We hypothesized that in PPARG mutations, abnormal adipose tissue triglyceride storage causes insulin resistance. DESIGN, PATIENTS, AND MAIN OUTCOME MEASURES: Whole-body and adipose tissue-specific metabolic phenotyping through arteriovenous blood sampling was made before and after a mixed meal including 13C-palmitic acid. Studies...

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Authors: Tan, G; Savage, D; Fielding, B; Collins, J; Hodson, L

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 93
• Issue: 11
• Pages: 4462-4470
• Publication date: 2008-11-01
• DOI: 10.1210/jc.2007-2356
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Lipodystrophy, Familial Partial; Adipose Tissue; Fatty Acids; Mutation; Humans; Reference Values; Diabetes Mellitus, Type 2; Adult; Thiazolidinediones; Amino Acid Substitution; Fatty Acids, Nonesterified; PPAR gamma; Hypoglycemic Agents; Palmitic Acid; Male; Heterozygote Detection; Insulin Resistance; Lipoproteins