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Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia

Abstract:

We previously demonstrated that hexokinase II (HK2) dissociation from mitochondria during cardiac ischemia correlates with cytochrome c (cyt-c) loss, oxidative stress and subsequent reperfusion injury. However, whether HK2 release is the primary signal mediating this ischemia-induced mitochondrial dysfunction was not established. To investigate this, we studied the effects of dissociating HK2 from isolated heart mitochondria. Mitochondria isolated from Langendorff-perfused rat hearts before a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0234653

Authors


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Role:
Author
ORCID:
0000-0001-9638-0615
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
Public Library of Science
Journal:
PloS One More from this journal
Volume:
15
Issue:
6
Article number:
e0234653
Place of publication:
United States
Publication date:
2020-06-24
Acceptance date:
2020-05-31
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Pmid:
32579577

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