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Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancer

Abstract:

Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of <1%. With little improvement in survival rates observed in the past 40 years, there is a significant need for new treatments or more effective strategies to deliver existing treatments. The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is known to produce significant side effects when administered systemically. We have previously d...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.jconrel.2018.04.018

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Publisher:
Elsevier Publisher's website
Journal:
Journal of Controlled Release Journal website
Volume:
279
Pages:
8-16
Publication date:
2018-04-11
Acceptance date:
2018-04-09
DOI:
ISSN:
0168-3659
Pubs id:
pubs:836611
URN:
uri:89ab3174-61ab-42fa-9901-b3559b6183f0
UUID:
uuid:89ab3174-61ab-42fa-9901-b3559b6183f0
Local pid:
pubs:836611

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