Chromosomal localization of murine interleukin-1 alpha and beta genes.

Journal article

DNA analyses of mouse X Chinese hamster somatic cell hybrids and of recombinant inbred mouse strains have previously shown that the interleukin-1 alpha and beta genes are tightly linked on murine chromosome 2, approximately 4.7 cM distal to beta-2-microglobulin. In this study, using in situ chromosome hybridization, we show that the two interleukin-1 genes are located in the F region of murine chromosome 2 and discuss this physical map position in relation to conserved genetic linkage groups.

Authors: Boultwood, J; Breckon, G; Birch, D; Cox, R

• Journal: Genomics
• Volume: 5
• Issue: 3
• Pages: 481-485
• Publication date: 1989-10-01
• DOI: 10.1016/0888-7543(89)90013-x
• EISSN: 1089-8646
• ISSN: 0888-7543
• Language: English
• Keywords: Animals; Chromosome Mapping; DNA; Interleukin-1; Male; Mice, Inbred CBA; Cricetinae; Mice; Genes; Chromosome Banding; Karyotyping