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The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial

Abstract:

Background
The use of placebos in randomised controlled trials is a subject of considerable ethical debate. In this paper we present a set of considerations to evaluate the ethics of placebo controlled trials that includes: social value of the study; need for a randomised controlled trial and placebo; standards of care; risks of harm due to administration of placebo and the harm benefit balance; clinical equipoise; and double standards. We illustrate the application of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12910-018-0259-4

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
ORCID:
0000-0003-2000-2874
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medical Ethics Journal website
Volume:
19
Pages:
Article: 19
Publication date:
2018-03-06
Acceptance date:
2018-02-26
DOI:
EISSN:
1472-6939
ISSN:
1472-6939
Pubs id:
pubs:828719
URN:
uri:899fbec9-2135-4e89-a6d5-7a53517a0dbb
UUID:
uuid:899fbec9-2135-4e89-a6d5-7a53517a0dbb
Local pid:
pubs:828719

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