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Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

Abstract:

Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF, and epigenetic modifications termed the CpG Island Methylator Phenotype, leading to epigenetic silencing of key tumour suppressor genes. It is still not clear which (epi-)genetic changes are most important in neoplastic progr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/gutjnl-2017-315920

Authors


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Cancer Council SA Beat Cancer Project More from this funder
Department of Health SA More from this funder
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Gut Journal website
Publication date:
2018-04-17
Acceptance date:
2018-03-27
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
Pmid:
29666172
Source identifiers:
843492
Language:
English
Keywords:
Pubs id:
pubs:843492
UUID:
uuid:898e9b5a-7eef-44a7-bf35-6207a2e4ab6e
Local pid:
pubs:843492
Deposit date:
2018-04-25

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