Journal article
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
- Abstract:
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Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF, and epigenetic modifications termed the CpG Island Methylator Phenotype, leading to epigenetic silencing of key tumour suppressor genes. It is still not clear which (epi-)genetic changes are most important in neoplastic progr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
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- Files:
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(pdf, 3.3MB)
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- Publisher copy:
- 10.1136/gutjnl-2017-315920
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Authors
Funding
Bibliographic Details
- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- Gut Journal website
- Publication date:
- 2018-04-17
- Acceptance date:
- 2018-03-27
- DOI:
- EISSN:
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1468-3288
- ISSN:
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0017-5749
- Pubs id:
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pubs:843492
- URN:
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uri:898e9b5a-7eef-44a7-bf35-6207a2e4ab6e
- UUID:
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uuid:898e9b5a-7eef-44a7-bf35-6207a2e4ab6e
- Local pid:
- pubs:843492
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- © Lannagan, et al 2018. All rights reserved.
- Copyright date:
- 2018
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from BMJ Publishing GRoup at: 10.1136/gutjnl-2017-315920
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