Journal article : Review
Recent advances in microneedle-based sensors for sampling, diagnosis and monitoring of chronic diseases
- Abstract:
- Chronic diseases (CDs) are noncommunicable illnesses with long-term symptoms accounting for ~70% of all deaths worldwide. For the diagnosis and prognosis of CDs, accurate biomarker detection is essential. Currently, the detection of CD-associated biomarkers is employed through complex platforms with certain limitations in their applicability and performance. There is hence unmet need to present innovative strategies that are applicable to the point-of-care (PoC) settings, and also, provide the precise detection of biomarkers. On the other hand, especially at PoC settings, microneedle (MN) technology, which comprises micron-size needles arranged on a miniature patch, has risen as a revolutionary approach in biosensing strategies, opening novel horizons to improve the existing PoC devices. Various MN-based platforms have been manufactured for distinctive purposes employing several techniques and materials. The development of MN-based biosensors for real-time monitoring of CD-associated biomarkers has garnered huge attention in recent years. Herein, we summarize basic concepts of MNs, including microfabrication techniques, design parameters, and their mechanism of action as a biosensing platform for CD diagnosis. Moreover, recent advances in the use of MNs for CD diagnosis are introduced and finally relevant clinical trials carried out using MNs as biosensing devices are highlighted. This review aims to address the potential use of MNs in CD diagnosis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 2.4MB, Terms of use)
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- Publisher copy:
- 10.3390/bios11090296
Authors
- Publisher:
- MDPI
- Journal:
- Biosensors More from this journal
- Volume:
- 11
- Issue:
- 9
- Article number:
- 296
- Place of publication:
- Switzerland
- Publication date:
- 2021-08-25
- Acceptance date:
- 2021-08-20
- DOI:
- EISSN:
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2079-6374
- Pmid:
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34562886
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1582315
- Local pid:
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pubs:1582315
- Deposit date:
-
2024-06-25
Terms of use
- Copyright holder:
- Erdem et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
- Licence:
- CC Attribution (CC BY)
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