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Saccharomyces cerevisiae RAD5 influences the excision repair of DNA minor groove adducts.

Abstract:

Nucleotide excision repair (NER) is the primary pathway for the removal of DNA adducts that distort the double helix. In the yeast Saccharomyces cerevisiae the RAD6 epistasis group defines a more poorly characterized set of DNA damage response pathways, believed to be distinct from NER. Here we show that the elimination of the DNA minor groove adducts formed by an important class of anticancer antibiotic (CC-1065 family) requires NER factors in S. cerevisiae. We also demonstrate that the elim...

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Publisher copy:
10.1074/jbc.m208169200
Journal:
Journal of biological chemistry More from this journal
Volume:
277
Issue:
46
Pages:
44576-44581
Publication date:
2002-11-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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