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First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease.

Abstract:

BACKGROUND: Patients with chronic kidney disease are at increased risk for cardiovascular disease, but the efficacy and safety of simvastatin and aspirin are unknown in this patient group. METHODS: Patients were randomly assigned in a 2 x 2 factorial design to the administration of: (1) 20 mg of simvastatin daily versus matching placebo, and (2) 100 mg of modified-release aspirin daily versus matching placebo. RESULTS: Overall, 448 patients with chronic kidney disease were randomly assigned (...

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Publication status:
Published

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Publisher copy:
10.1053/j.ajkd.2004.11.015

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Journal:
American journal of kidney diseases : the official journal of the National Kidney Foundation
Volume:
45
Issue:
3
Pages:
473-484
Publication date:
2005-03-05
DOI:
EISSN:
1523-6838
ISSN:
0272-6386
URN:
uuid:896190ac-ade4-4764-802b-eee167387a04
Source identifiers:
23149
Local pid:
pubs:23149

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