- Abstract:
-
BACKGROUND: Patients with chronic kidney disease are at increased risk for cardiovascular disease, but the efficacy and safety of simvastatin and aspirin are unknown in this patient group. METHODS: Patients were randomly assigned in a 2 x 2 factorial design to the administration of: (1) 20 mg of simvastatin daily versus matching placebo, and (2) 100 mg of modified-release aspirin daily versus matching placebo. RESULTS: Overall, 448 patients with chronic kidney disease were randomly assigned (...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1053/j.ajkd.2004.11.015
-
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- Journal:
- American journal of kidney diseases : the official journal of the National Kidney Foundation
- Volume:
- 45
- Issue:
- 3
- Pages:
- 473-484
- Publication date:
- 2005-03-05
- DOI:
- EISSN:
-
1523-6838
- ISSN:
-
0272-6386
- URN:
-
uuid:896190ac-ade4-4764-802b-eee167387a04
- Source identifiers:
-
23149
- Local pid:
- pubs:23149
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease.
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