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System-level feedbacks make the anaphase switch irreversible.

Abstract:

The mitotic checkpoint prevents a eukaryotic cell from commencing to separate its replicated genome into two daughter cells (anaphase) until all of its chromosomes are properly aligned on the metaphase plate, with the two copies of each chromosome attached to opposite poles of the mitotic spindle. The mitotic checkpoint is exquisitely sensitive in that a single unaligned chromosome, 1 of a total of ~50, is sufficient to delay progression into anaphase; however, when the last chromosome comes ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1102106108

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
108
Issue:
24
Pages:
10016-10021
Publication date:
2011-06-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:141775
UUID:
uuid:89612d53-536d-4ea6-baa9-6cb50ab35e8e
Local pid:
pubs:141775
Source identifiers:
141775
Deposit date:
2012-12-19

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