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Circulating beta-carotene levels and type 2 diabetes-cause or effect?

Abstract:

AIMS/HYPOTHESIS: Circulating beta-carotene levels are inversely associated with risk of type 2 diabetes, but the causal direction of this association is not certain. In this study we used a Mendelian randomisation approach to provide evidence for or against the causal role of the antioxidant vitamin beta-carotene in type 2 diabetes. METHODS: We used a common polymorphism (rs6564851) near the BCMO1 gene, which is strongly associated with circulating beta-carotene levels (p = 2 x 10(-24)), wit...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-009-1475-8

Authors


Ferrucci, L More by this author
Bandinelli, S More by this author
Guralnik, J More by this author
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Journal:
Diabetologia
Volume:
52
Issue:
10
Pages:
2117-2121
Publication date:
2009-10-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:895e89a0-51f2-4719-a7fe-7564bc345deb
Source identifiers:
26904
Local pid:
pubs:26904

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