Journal article
Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo.
- Abstract:
-
Regulatory T cells (T(reg)) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote T(reg) expansion. Here, we hypothesized that adjunctive rapamycin therapy might potentiate the ability of ex vivo expanded human T(reg) to inhibit vascular allograft rejection in a humanized mouse model of arterial transplantation. We studied the influence of combined treatment wi...
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- Publication status:
- Published
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- Publisher copy:
- 10.1111/j.1600-6143.2012.04065.x
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Bibliographic Details
- Journal:
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Volume:
- 12
- Issue:
- 8
- Pages:
- 2008-2016
- Publication date:
- 2012-08-05
- DOI:
- EISSN:
-
1600-6143
- ISSN:
-
1600-6135
- URN:
-
uuid:894bcc7a-a797-43d9-9fc9-078ecfb91758
- Source identifiers:
-
348924
- Local pid:
- pubs:348924
Item Description
Terms of use
- Copyright date:
- 2012
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