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Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo.

Abstract:

Regulatory T cells (T(reg)) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote T(reg) expansion. Here, we hypothesized that adjunctive rapamycin therapy might potentiate the ability of ex vivo expanded human T(reg) to inhibit vascular allograft rejection in a humanized mouse model of arterial transplantation. We studied the influence of combined treatment wi...

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Publication status:
Published

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Authors


Schiopu, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Journal:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume:
12
Issue:
8
Pages:
2008-2016
Publication date:
2012-08-05
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
URN:
uuid:894bcc7a-a797-43d9-9fc9-078ecfb91758
Source identifiers:
348924
Local pid:
pubs:348924

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