Large-scale unselected community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people

Journal article

Background

Valvular heart disease (VHD) is expected to become more common as the population ages. However, current estimates of its natural history and prevalence are based on historical studies with potential sources of bias. We conducted a cross-sectional analysis of the clinical and epidemiological characteristics of VHD identified at recruitment of a large cohort of older people.

Methods and Results

We enrolled 2500 individuals aged ≥65 years from a primary care population and screened for undiagnosed VHD using transthoracic echocardiography. Newly identified (predominantly mild) VHD was detected in 51% of participants. The most common abnormalities were aortic sclerosis (34%), mitral regurgitation (22%), and aortic regurgitation (15%). Aortic stenosis was present in 1.3%. The likelihood of undiagnosed VHD was 2-fold higher in the two most deprived socioeconomic quintiles than in the most affluent quintile, and 3-fold higher in individuals with atrial fibrillation.

Clinically significant (moderate or severe) undiagnosed VHD was identified in 6.4%. In addition, 4.9% of the cohort had pre-existing VHD (a total prevalence of 11.3%). Projecting these findings using population data, we estimate that the prevalence of clinically significant VHD will double before 2050.

Conclusions

Previously undetected VHD affects 1 in 2 of the elderly population and is more common in lower socioeconomic classes. These unique data demonstrate the contemporary clinical and epidemiological characteristics of VHD in a large population-based cohort of older people and confirm the scale of the emerging epidemic of VHD, with widespread implications for clinicians and healthcare resources.

Authors: d'Arcy, J; Loudon, M; Kennedy, A; Birks, J; Frangou, E

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: European Heart Journal
• Publication date: 2016-05-01
• Acceptance date: 2016-05-18
• DOI: 10.1093/eurheartj/ehw229
• ISSN: 1522-9645
• Keywords: Epidemiology; Health policy and outcome research; Valvular heart disease; Echocardiography