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Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets

Abstract:

Human islet isolation is associated with adverse conditions inducing apoptosis and necrosis. The aim of the present study was to assess whether antiapoptotic preconditioning can improve in vitro and posttransplant function of isolated human islets. A dose-finding study demonstrated that 200 μmol/L of the caspase-3 inhibitor Ac-DEVD-CMK was most efficient to reduce the expression of activated caspase-3 in isolated human islets exposed to severe heat shock. Ac-D...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s10495-013-0834-6

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
St Edmund Hall
Role:
Author
Publisher:
Springer Publisher's website
Journal:
Apoptosis Journal website
Volume:
18
Issue:
6
Pages:
681-688
Publication date:
2013-03-28
DOI:
EISSN:
1573-675X
ISSN:
1360-8185
Pmid:
23536200
Source identifiers:
383061
Language:
English
Keywords:
Pubs id:
pubs:383061
UUID:
uuid:89319740-a752-495f-a40a-e97098a4d0d9
Local pid:
pubs:383061
Deposit date:
2018-08-28

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