The impact of age on outcome in lymphoblastic leukaemia; MRC UKALL X and XA compared: a report from the MRC Paediatric and Adult Working Parties.

Journal article

The purpose of the study was to examine the influence of age on outcome in a large cohort of children and adults with lymphoblastic leukaemia who were treated on two similar trials. Factors influencing outcome were examined in 2204 patients aged over 1 year treated between 1985 and 1992 on the parallel Medical Research Council Trials UKALL X and XA, for children and adults, respectively. There was a progressive worsening in survival with increasing age from 85% (95% CI 83-87) at 5 years for c...

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Authors: Chessells, J; Hall, E; Prentice, H; Durrant, J; Bailey, C

• Publication status: Published
• Journal: Leukemia
• Volume: 12
• Issue: 4
• Pages: 463-473
• Publication date: 1998-04-01
• DOI: 10.1038/sj.leu.2400959
• EISSN: 1476-5551
• ISSN: 0887-6924
• Language: English
• Keywords: Female; Adult; Infant; Prognosis; Treatment Outcome; Disease-Free Survival; Humans; Adolescent; Child, Preschool; Antineoplastic Combined Chemotherapy Protocols; Proportional Hazards Models; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Middle Aged; Child; Male; Aging; Multivariate Analysis