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Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event

Abstract:

Streptococcus pneumoniae ('pneumococcus') causes an estimated 14.5 million cases of serious disease and 826,000 deaths annually in children under 5 years of age. The highly effective introduction of the PCV7 pneumococcal vaccine in 2000 in the United States provided an unprecedented opportunity to investigate the response of an important pathogen to widespread, vaccine-induced selective pressure. Here, we use array-based sequencing of 62 isolates from a US national monitoring program to study...

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Publisher copy:
10.1038/ng.1072

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Brueggemann, AB More by this author
Spencer, CCA More by this author
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Journal:
Nature Genetics
Volume:
44
Issue:
3
Pages:
352-355
Publication date:
2012-03-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:890a9093-a81d-45a9-b2be-1df7933c6a8e
Source identifiers:
319779
Local pid:
pubs:319779
Language:
English

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