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Annonacin exerts antitumor activity through induction of apoptosis and extracellular signal-regulated kinase inhibition

Abstract:

Background: Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries. Annonacin, a natural pure compound extracted from the seeds of Annona muricata, is a potential alternative therapeutic agent to treat EC. 

Objective: To study the antitumor activity of annonacin and its mechanism of action in EC cells (ECCs). 

Materials and Methods: Viability of ECCs treated with annonacin for 72 h w...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.4103/pr.pr_19_17

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics & Gynaecology
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Grant:
Research Grant (RP019b)
Publisher:
Medknow Publications Publisher's website
Journal:
Pharmacognosy Research Journal website
Volume:
9
Issue:
4
Pages:
378-383
Publication date:
2017-11-16
Acceptance date:
2017-04-26
DOI:
ISSN:
0976-4836
Pubs id:
pubs:747112
URN:
uri:890377f3-1dc6-4a7e-8e1e-f9225007659a
UUID:
uuid:890377f3-1dc6-4a7e-8e1e-f9225007659a
Local pid:
pubs:747112

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