Annonacin exerts antitumor activity through induction of apoptosis and extracellular signal-regulated kinase inhibition
Background: Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries. Annonacin, a natural pure compound extracted from the seeds of Annona muricata, is a potential alternative therapeutic agent to treat EC.
Objective: To study the antitumor activity of annonacin and its mechanism of action in EC cells (ECCs).
Materials and Methods: Viability of ECCs treated with annonacin for 72 h w...Expand abstract
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