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Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria

Abstract:

The outer membrane (OM) of Gram-negative bacteria is a unique asymmetric lipid bilayer in which the outer leaflet is composed of lipopolysaccharide (LPS) and the inner leaflet is formed by glycerophospholipid (GPL). The OM plays a fundamental role in protecting Gram-negative bacteria from harsh environments and toxic compounds. The transport and assembly pathways for phospholipids of bacterial OM are unknown. Cardiolipin (CL) plays an important role in OM biogenesis and pathogenesis, and the ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep30815

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Structural Genomics Consortium
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Issue:
1
Pages:
30815
Publication date:
2016-08-04
Acceptance date:
2016-07-08
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:638307
URN:
uri:88e33dd3-70a1-45b7-8add-f5eda6251b7e
UUID:
uuid:88e33dd3-70a1-45b7-8add-f5eda6251b7e
Local pid:
pubs:638307

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