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Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease.

Abstract:

BACKGROUND: A major clinical feature in multiple myeloma is the development of osteolytic bone disease. The increase in bone destruction is due to uncontrolled osteoclastic bone resorption. Until recently the factors responsible for mediating the increase in osteoclast formation in myeloma have been unclear. However, recent studies have implicated a number of factors, including the ligand for receptor activator of NFkappaB (RANKL) and macrophage inflammatory protein-1alpha. The demonstration...

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Publication status:
Published

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Publisher copy:
10.1002/cncr.11125

Authors


Croucher, PI More by this author
Shipman, CM More by this author
Van Camp, B More by this author
Vanderkerken, K More by this author
Journal:
Cancer
Volume:
97
Issue:
3 Suppl
Pages:
818-824
Publication date:
2003-02-05
DOI:
EISSN:
1097-0142
ISSN:
0008-543X
URN:
uuid:88dc92ae-ae43-41ca-9218-33bc2cd4b2b2
Source identifiers:
112821
Local pid:
pubs:112821

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