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Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax.

Abstract:

In this review we present recent developments in the analysis of Plasmodium vivax clinical trials and ex vivo drug-susceptibility assays, as well approaches currently being used to identify molecular markers of drug resistance. Clinical trials incorporating the measurement of in vivo drug concentrations and parasite clearance times are needed to detect early signs of resistance. Analysis of P. vivax growth dynamics ex vivo have defined the criteria for acceptable assay thresholds for drug sus...

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Publication status:
Published

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Publisher copy:
10.1016/j.pt.2012.08.005

Authors


Marfurt, J More by this author
Journal:
Trends in parasitology
Volume:
28
Issue:
11
Pages:
522-529
Publication date:
2012-11-05
DOI:
EISSN:
1471-5007
ISSN:
1471-4922
URN:
uuid:88da5b9f-f737-454c-aa8b-b487b55eac8b
Source identifiers:
353949
Local pid:
pubs:353949

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