Journal article
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
- Abstract:
-
Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-re...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Nature Publications
- Journal:
- Nature Communications More from this journal
- Volume:
- 7
- Pages:
- Article 10979
- Publication date:
- 2016-04-07
- Acceptance date:
- 2016-02-03
- DOI:
- ISSN:
-
2041-1723
- Pmid:
-
27052111
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:616779
- UUID:
-
uuid:88d18fcb-09b2-4554-ada4-45d9444c621c
- Local pid:
- pubs:616779
- Source identifiers:
-
616779
- Deposit date:
- 2017-10-31
Terms of use
- Copyright holder:
- Gusev et al
- Copyright date:
- 2016
- Notes:
-
This work is licensed under a Creative Commons Attribution 4.0
International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
- Licence:
- CC Attribution (CC BY)
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