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AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome

Abstract:

Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder, occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a defining feature of PCOS and has been suggested as causally associated with insulin resistance; however, mechanistic evidence linking both is lacking. We hypothesized that adipose tissue is an important site linking androgen activation and metabolic dysfunction in PCOS.We performed a hu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1210/jc.2017-00947

Authors


O'Reilly, MW More by this author
Kempegowda, P More by this author
Taylor, AE More by this author
Manolopoulos, KN More by this author
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Grant:
Clinical Research Training Fellowship 099909 to M.W.O.
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Grant:
NIHR Liver Biomedical Research Unit, Birmingham to W.A.
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Clinical Endocrinology and Metabolism Journal website
Volume:
102
Issue:
9
Pages:
3327–3339
Publication date:
2017-06-22
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Pubs id:
pubs:702445
URN:
uri:88aec93d-98ef-4135-81ed-0f4818bb3c8b
UUID:
uuid:88aec93d-98ef-4135-81ed-0f4818bb3c8b
Local pid:
pubs:702445
Language:
English

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