Journal article
AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome
- Abstract:
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Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder, occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a defining feature of PCOS and has been suggested as causally associated with insulin resistance; however, mechanistic evidence linking both is lacking. We hypothesized that adipose tissue is an important site linking androgen activation and metabolic dysfunction in PCOS.We performed a hu...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1210/jc.2017-00947
Authors
Funding
+ National Institutes of
Health Research
More from this funder
Grant:
NIHR Biomedical Research Center
Oxford to J.W.T
+ Biotechnology and Biological Sciences Research
Council
More from this funder
Grant:
BB/L006340/1 to D.H
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Journal of Clinical Endocrinology and Metabolism More from this journal
- Volume:
- 102
- Issue:
- 9
- Pages:
- 3327–3339
- Publication date:
- 2017-06-22
- Acceptance date:
- 2017-06-09
- DOI:
- EISSN:
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1945-7197
- ISSN:
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0021-972X
- Pmid:
-
28645211
Item Description
- Language:
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English
- Pubs id:
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pubs:702445
- UUID:
-
uuid:88aec93d-98ef-4135-81ed-0f4818bb3c8b
- Local pid:
-
pubs:702445
- Source identifiers:
-
702445
- Deposit date:
-
2017-09-15
Terms of use
- Copyright holder:
- O’Reilly et al
- Copyright date:
- 2017
- Notes:
- This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the authors.
- Licence:
- CC Attribution (CC BY)
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