Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder, occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a defining feature of PCOS and has been suggested as causally associated with insulin resistance; however, mechanistic evidence linking both is lacking. We hypothesized that adipose tissue is an important site linking androgen activation and metabolic dysfunction in PCOS.We performed a hu...Expand abstract
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- Clinical Research Training Fellowship 099909 to M.W.O.
- BB/L006340/1 to D.H.
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- Journal of Clinical Endocrinology and Metabolism Journal website
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AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome
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