Journal article icon

Journal article

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Abstract:

Haematopoietic stem cells (HSCs) maintain lifelong blood production and increase blood cell numbers in response to chronic and acute injury. However, the mechanism(s) by which inflammatory insults are communicated to HSCs and their consequences for HSC activity remain largely unknown. Here, we demonstrate that interleukin-1 (IL-1), which functions as a key pro-inflammatory 'emergency' signal, directly accelerates cell division and myeloid differentiation of HSCs through precocious activation ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/ncb3346

Authors


Expand authors...
NIDDK NIH HHS More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Cell Biology Journal website
Volume:
18
Pages:
607–618
Publication date:
2016-04-25
Acceptance date:
2016-03-24
DOI:
ISSN:
1476-4679 and 1465-7392
Pmid:
27111842
Language:
English
Keywords:
Pubs id:
pubs:619554
UUID:
uuid:8887a763-6105-4a81-86d4-45e5f1bfe23c
Local pid:
pubs:619554
Deposit date:
2016-11-01

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP