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Improving orthogonality in two-component biological signalling systems using feedback control

Abstract:

In natural biological systems, cellular responses to changing growth and environmental conditions are governed by complex signalling and control networks. A common signalling motif is that of the two component signalling systems (TCSSs), dozens of which may operate simultaneously in a single cell. When synthetic biologists create new signalling networks in living cells, achieving orthogonality of signal transmission can be difficult. One challenge is overcoming the crosstalk between pathways ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1109/lcsys.2018.2871663

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
ORCID:
0000-0002-9625-4755
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
ORCID:
0000-0003-4666-4454
More by this author
Role:
Author
ORCID:
0000-0001-7003-0393
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0002-3565-8967
Publisher:
IEEE Publisher's website
Journal:
IEEE Control Systems Letters Journal website
Volume:
3
Issue:
2
Pages:
326-331
Publication date:
2018-09-24
Acceptance date:
2018-09-04
DOI:
ISSN:
2475-1456
Pubs id:
pubs:948295
URN:
uri:887eb903-5fdd-4756-a4fb-cb4075160ff6
UUID:
uuid:887eb903-5fdd-4756-a4fb-cb4075160ff6
Local pid:
pubs:948295

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