Deoxyhaemoglobin as a biomarker of cerebral autoregulation

Journal article

Cerebral autoregulation (CA) maintains cerebral blood flow over a range of perfusion pressure. Continuous CA monitoring might define pressure targets minimising secondary brain injury, but application is limited by available monitoring modalities. Near-infrared spectroscopy (NIRS) is a noninvasive optical technique characterising aspects of CA. The NIRS-derived tissue oxygenation index (TOI) is correlated with blood pressure (BP) to produce an index of vascular reactivity (TOx) [1]. The contribution from extracerebral tissues, optical complexity of injured brain and complex physiology represented by NIRS are likely to limit agreement with other techniques. NIRS-measured deoxyhaemoglobin (HHb) may have advantages as its physiological confounds are less complicated and are predominantly in the cerebral venous circulation. This study compares HHb with established indices of reactivity - the mean velocity index (Mx) and oxygen reactivity index (ORx).

Authors: Highton, D; Ghosh, A; Tachtsidis, I; Kolyva, C; Panovska, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: BioMed Central
• Journal: Critical Care
• Volume: 16
• Issue: S1
• Pages: p295
• Publication date: 2012-03-20
• DOI: 10.1186/cc10902
• EISSN: 1364-8535
• ISSN: 1364-8535
• Language: English
• Keywords: Biomarker; Cerebral autoregulation; Autoregulation; Perfusion; Cerebral blood flow; Medicine; Cerebral circulation; Cerebral perfusion pressure; Internal medicine; Blood pressure; Chemistry; Blood flow; Anesthesia; Cardiology; Oxygenation