Journal article
Programmable one-pot multistep organic synthesis using DNA junctions.
- Abstract:
- A system for multistep DNA-templated synthesis is controlled by the sequential formation of DNA junctions. Reactants are attached to DNA adapters which are brought together by hybridization to DNA template strands. This process can be repeated to allow sequence-controlled oligomer synthesis while maintaining a constant reaction environment, independent of oligomer length, at each reaction step. Synthesis can take place in a single pot containing all required reactive monomers. Different oligomers can be synthesized in parallel in the same vessel, and the products of parallel synthesis can be ligated, reducing the number of reaction steps required to produce an oligomer of a given length.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Preview, Accepted manuscript, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1021/ja2101196
Authors
- Publisher:
- American Chemical Society
- Journal:
- Journal of the American Chemical Society More from this journal
- Volume:
- 134
- Issue:
- 3
- Pages:
- 1446-1449
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1520-5126
- ISSN:
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0002-7863
- Language:
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English
- Keywords:
- Pubs id:
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pubs:245550
- UUID:
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uuid:884ae207-93af-4bfe-9e5b-c7e9c81f4883
- Local pid:
-
pubs:245550
- Source identifiers:
-
245550
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2012
- Notes:
- This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/ja2101196. Copyright 2012 American Chemical Society.
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