10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial.

Journal article

Background

If carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the longterm effects of successful CEA.

Methods

Between 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were allocated equally, by blinded minimised randomisation, to immediate CEA (median delay 1 month [IQR 0·3–2·5]) or to...

Expand abstract

Authors: Halliday, A; Harrison, M; Hayter, E; Kong, X; Mansfield, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Lancet (London, England)
• Volume: 376
• Issue: 9746
• Pages: 1074-1084
• Publication date: 2010-09-01
• DOI: 10.1016/s0140-6736(10)61197-x
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Middle Aged; Carotid Stenosis; Treatment Outcome; Humans; Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group; Kaplan-Meier Estimate; Aged; Stroke; Endarterectomy, Carotid; Incidence; Time Factors; Aged, 80 and over; Female; Male; Primary Prevention