Journal article

Inhibition of a viral prolyl hydroxylase

Abstract:: The hydroxylation of prolyl-residues in eukaryotes is important in collagen biosynthesis and in hypoxic signalling. The hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are drug targets for the treatment of anaemia, while the procollagen prolyl hydroxylases and other 2-oxoglutarate dependent oxygenases are potential therapeutic targets for treatment of cancer, fibrotic disease, and infection. We describe assay development and inhibition studies for a procollagen prolyl hydroxylase from Paramecium bursaria chlorella virus 1 (vCPH). The results reveal HIF PHD inhibitors in clinical trials also inhibit vCPH. Implications for the targeting of the human PHDs and microbial prolyl hydroxylases are discussed.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Langley, G., Abboud, M., Lohans, C., & Schofield, C. (2019). Inhibition of a viral prolyl hydroxylase. Bioorganic and Medicinal Chemistry, 27(12), 2405–2412.

MLA Style

Langley, G., et al. “Inhibition of a Viral Prolyl Hydroxylase.” Bioorganic and Medicinal Chemistry, vol. 27, no. 12, Elsevier, 2019, pp. 2405–12.

Chicago Style

Langley, G, M Abboud, C Lohans, and C Schofield. 2019. “Inhibition of a Viral Prolyl Hydroxylase.” Bioorganic and Medicinal Chemistry 27 (12): 2405–12.
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Publisher copy:: 10.1016/j.bmc.2019.01.018

Authors

+ Langley, G More by this author

Role:: Author
ORCID:: 0000-0003-0875-3712

+ Abboud, M More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author
ORCID:: 0000-0003-2141-5988

+ Lohans, C More by this author

Institution:: University of Oxford
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Schofield, C More by this author

Institution:: University of Oxford
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author
ORCID:: 0000-0002-0290-6565

Publisher:: Elsevier
Journal:: Bioorganic and Medicinal Chemistry More from this journal
Volume:: 27
Issue:: 12
Pages:: 2405-2412
Publication date:: 2019-01-23
Acceptance date:: 2019-01-21
DOI:: 10.1016/j.bmc.2019.01.018
EISSN:: 1464-3391
ISSN:: 0968-0896
Pmid:: 30737136

Language:: English
Keywords:: FFR

2-oxoglutarate

collagen biosynthesis

hypoxia inducible factor

prolyl hydroxylase inhibitor

erythropoietin (EPO)
Pubs id:: pubs:972927
UUID:: uuid:8838de20-f9f2-4954-9a8a-1bcb7d423d27
Local pid:: pubs:972927
Source identifiers:: 972927
Deposit date:: 2019-03-12

Terms of use

Copyright holder:: Elsevier Ltd
Copyright date:: 2019
Rights statement:: © 2019 Published by Elsevier Ltd.
Notes:: This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.bmc.2019.01.018

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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