Journal article
Inhibition of a viral prolyl hydroxylase
- Abstract:
-
The hydroxylation of prolyl-residues in eukaryotes is important in collagen biosynthesis and in hypoxic signalling. The hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are drug targets for the treatment of anaemia, while the procollagen prolyl hydroxylases and other 2-oxoglutarate dependent oxygenases are potential therapeutic targets for treatment of cancer, fibrotic disease, and infection. We describe assay development and inhibition studies for a procollagen prolyl hydroxylase fr...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Bioorganic and Medicinal Chemistry Journal website
- Volume:
- 27
- Issue:
- 12
- Pages:
- 2405-2412
- Publication date:
- 2019-01-23
- Acceptance date:
- 2019-01-21
- DOI:
- EISSN:
-
1464-3391
- ISSN:
-
0968-0896
- Pmid:
-
30737136
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:972927
- UUID:
-
uuid:8838de20-f9f2-4954-9a8a-1bcb7d423d27
- Local pid:
- pubs:972927
- Source identifiers:
-
972927
- Deposit date:
- 2019-03-12
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2019
- Rights statement:
- © 2019 Published by Elsevier Ltd.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.bmc.2019.01.018
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record