Journal article

Synthesis and reactivity of (18)F-labeled α,α-Difluoro-α-(aryloxy)acetic acids.

Abstract:: In this work, we describe the (18)F-labeling of α,α-difluoro-α-(aryloxy)acetic acid derivatives and demonstrate that these building blocks are amenable to post-(18)F-fluorination functionalization. Protodecarboxylation offers a new entry to (18)F-difluoromethoxyarene, and the value of this approach is further demonstrated with coupling processes leading to representative (18)F-labeled TRPV1 inhibitors and TRPV1 antagonists.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Khotavivattana, T., Calderwood, S., Verhoog, S., Pfeifer, L., Preshlock, S., Vasdev, N., Collier, T., & Gouverneur, V. (2017). Synthesis and reactivity of (18)F-labeled α,α-Difluoro-α-(aryloxy)acetic acids. Organic Letters, 19(3), 568–571.

MLA Style

Khotavivattana, T., et al. “Synthesis and Reactivity of (18)F-Labeled α,α-Difluoro-α-(Aryloxy)Acetic Acids.” Organic Letters, vol. 19, no. 3, American Chemical Society, 2017, pp. 568–71.

Chicago Style

Khotavivattana, T, S Calderwood, S Verhoog, L Pfeifer, S Preshlock, N Vasdev, T Collier, and V Gouverneur. 2017. “Synthesis and Reactivity of (18)F-Labeled α,α-Difluoro-α-(Aryloxy)Acetic Acids.” Organic Letters 19 (3): 568–71.
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Publisher copy:: 10.1021/acs.orglett.6b03730

Authors

+ Khotavivattana, T More by this author

Role:: Author

+ Calderwood, S More by this author

Role:: Author

+ Verhoog, S More by this author

Role:: Author

+ Pfeifer, L More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Preshlock, S More by this author

Role:: Author

More authors...

+ Royal Society More from this funder

+ GlaxoSmithKline More from this funder

+ Cancer Research UK More from this funder

+ Medical Research Council More from this funder

+ Engineering and Physical Sciences Research Council More from this funder

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Publisher:: American Chemical Society
Journal:: Organic Letters More from this journal
Volume:: 19
Issue:: 3
Pages:: 568-571
Publication date:: 2017-01-01
DOI:: 10.1021/acs.orglett.6b03730
EISSN:: 1523-7060
ISSN:: 1523-7052

Language:: English
Keywords:: Journal Article
Pubs id:: pubs:671426
UUID:: uuid:8836bf2a-5f5b-44b1-a097-2f3df84c6158
Local pid:: pubs:671426
Source identifiers:: 671426
Deposit date:: 2017-08-01

Terms of use

Copyright date:: 2017

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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