Journal article
Synthesis and reactivity of (18)F-labeled α,α-Difluoro-α-(aryloxy)acetic acids.
- Abstract:
- In this work, we describe the (18)F-labeling of α,α-difluoro-α-(aryloxy)acetic acid derivatives and demonstrate that these building blocks are amenable to post-(18)F-fluorination functionalization. Protodecarboxylation offers a new entry to (18)F-difluoromethoxyarene, and the value of this approach is further demonstrated with coupling processes leading to representative (18)F-labeled TRPV1 inhibitors and TRPV1 antagonists.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1021/acs.orglett.6b03730
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Authors
Funding
Royal Thai Government
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Advion
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Engineering and Physical Sciences Research Council
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Medical Research Council
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Organic Letters Journal website
- Volume:
- 19
- Issue:
- 3
- Pages:
- 568-571
- Publication date:
- 2017-01-01
- DOI:
- EISSN:
-
1523-7060
- ISSN:
-
1523-7052
- Source identifiers:
-
671426
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:671426
- UUID:
-
uuid:8836bf2a-5f5b-44b1-a097-2f3df84c6158
- Local pid:
- pubs:671426
- Deposit date:
- 2017-08-01
Terms of use
- Copyright date:
- 2017
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