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Synthesis and reactivity of (18)F-labeled α,α-Difluoro-α-(aryloxy)acetic acids.

Abstract:
In this work, we describe the (18)F-labeling of α,α-difluoro-α-(aryloxy)acetic acid derivatives and demonstrate that these building blocks are amenable to post-(18)F-fluorination functionalization. Protodecarboxylation offers a new entry to (18)F-difluoromethoxyarene, and the value of this approach is further demonstrated with coupling processes leading to representative (18)F-labeled TRPV1 inhibitors and TRPV1 antagonists.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.orglett.6b03730

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Royal Thai Government More from this funder
Engineering and Physical Sciences Research Council More from this funder
Medical Research Council More from this funder
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Publisher:
American Chemical Society Publisher's website
Journal:
Organic Letters Journal website
Volume:
19
Issue:
3
Pages:
568-571
Publication date:
2017-01-01
DOI:
EISSN:
1523-7060
ISSN:
1523-7052
Source identifiers:
671426
Language:
English
Keywords:
Pubs id:
pubs:671426
UUID:
uuid:8836bf2a-5f5b-44b1-a097-2f3df84c6158
Local pid:
pubs:671426
Deposit date:
2017-08-01

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