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Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding.

Abstract:

The RNA polymerase of influenza A virus is a heterotrimeric complex of PB1, PB2 and PA subunits that is required for transcription and replication of the viral genome. Here, we demonstrate a differential requirement of the PA subunit for binding to the vRNA and cRNA promoters--specifically, PA is more important for binding to the cRNA than the vRNA promoter. Furthermore, five point mutations were identified in the L163-I178 region of PA, which resulted in an inhibition of polymerase activity ...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2007.08.029

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Virology
Volume:
370
Issue:
1
Pages:
194-204
Publication date:
2008-01-01
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
Source identifiers:
12292
Language:
English
Keywords:
Pubs id:
pubs:12292
UUID:
uuid:88183ff5-2e8e-4f1f-86f3-2f36ffed9535
Local pid:
pubs:12292
Deposit date:
2012-12-19

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