Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media.

Journal article

Defining the role of Staphylococcus aureus adhesins in disease pathogenesis may depend on the use of bacteria grown in culture media that more closely reflect the human milieu than conventional broth. This study examined the functional effect on S. aureus adhesins following growth in an ex vivo medium containing a complex mixture of human proteins (used peritoneal dialysate) relative to growth in Todd-Hewitt broth. The adherence of S. aureus, cultured in dialysate, to fibronectin and fibrinog...

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Authors: Massey, R; Dissanayeke, SR; Cameron, B; Ferguson, D; Foster, T

• Publication status: Published
• Journal: Infection and immunity
• Volume: 70
• Issue: 10
• Pages: 5339-5345
• Publication date: 2002-10-01
• DOI: 10.1128/iai.70.10.5339-5345.2002
• EISSN: 1098-5522
• ISSN: 0019-9567
• Language: English
• Keywords: Fibrinogen; Immunoglobulins; Microscopy, Electron; Humans; Protein Binding; Carrier Proteins; Bacterial Proteins; Adhesins, Bacterial; Culture Media; Bacterial Adhesion; Staphylococcus aureus; Virulence; Fibronectins; Staphylococcal Protein A; Genes, Bacterial